Retinal Bipolar Cells Through Multiple Calcium Channels in Goldfish Evidence that Exocytosis Is Driven by Calcium Entry
نویسندگان
چکیده
[PDF] [Full Text] [Abstract] , October, 14 2009; 29 (41): 12802-12806. J. Neurosci. and Alapakkam P. Sampath Joshua H. Singer, Elisabeth Glowatzki, Tobias Moser, Ben W. Strowbridge, Vikas Bhandawat Functional Properties of Synaptic Transmission in Primary Sense Organs [PDF] [Abstract] , December, 2009; 15 (6): 611-624. Neuroscientist Frank Schmitz The Making of Synaptic Ribbons: How They Are Built and What They Do [PDF] [Full Text] [Abstract] , January, 2010; 103 (1): 419-423. J Neurophysiol Theodore M. Bartoletti, Norbert Babai and Wallace B. Thoreson Vesicle Pool Size at the Salamander Cone Ribbon Synapse [PDF] [Full Text] [Abstract] , May, 1 2010; 588 (9): 1469-1487. J Physiol Leif Oltedal and Espen Hartveit exocytosis from axon terminals in rat retinal slices Transient release kinetics of rod bipolar cells revealed by capacitance measurement of [PDF] [Full Text] [Abstract] , September, 8 2010; 30 (36): 11885-11895. J. Neurosci. Tim Jarsky, Miao Tian and Joshua H. Singer Ribbon Synapse Nanodomain Control of Exocytosis Is Responsible for the Signaling Capability of a Retinal
منابع مشابه
Evidence that exocytosis is driven by calcium entry through multiple calcium channels in goldfish retinal bipolar cells.
Ribbon-containing neurons represent a subset of neural cells that undergo graded membrane depolarizations rather than Na(+)-channel evoked action potentials. Bipolar cells of the retina are one type of ribbon-containing neuron and extensive research has demonstrated kinetically distinct pools of vesicles that are released and replenished in a calcium-dependent manner. In this study, we look at ...
متن کاملSynaptic mechanisms of bipolar cell terminals
Giant synaptic terminals of goldfish bipolar neurons allow direct studies of presynaptic mechanisms underlying neurotransmitter release and its modulation. Calcium influx via L-type calcium channels of the terminal triggers synaptic vesicle exocytosis, which can be monitored in isolated terminals by means of the associated changes in membrane capacitance. Information about the kinetics and calc...
متن کاملCalcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.
Most retinal bipolar cells (BCs) transmit visual input from photoreceptors to ganglion cells using graded potentials, but some also generate calcium or sodium spikes. Sodium spikes are thought to increase temporal precision of light-evoked BC signaling; however, the role of calcium spikes in BCs is not fully understood. Here we studied how calcium spikes and graded responses mediate neurotransm...
متن کاملImaging calcium entry sites and ribbon structures in two presynaptic cells.
We investigated the location of calcium entry sites and synaptic ribbons in the type-Mb goldfish bipolar neuron and the bullfrog saccular hair cell. Cells were loaded with a fast calcium indicator (Fluo-3 or Fluo-5F) and an excess of a high-affinity but slow Ca buffer (EGTA). The cell surface was imaged by evanescent field microscopy. Small fluorescent "hot spots" representing calcium entry sit...
متن کاملTwo actions of calcium regulate the supply of releasable vesicles at the ribbon synapse of retinal bipolar cells.
Ribbon synapses of sensory neurons are able to sustain high rates of exocytosis in response to maintained depolarization, but it is not known how this is achieved. Using the capacitance technique, we have found that Ca(2+) regulates the supply of releasable vesicles at the ribbon synapse of depolarizing bipolar cells from the retina of goldfish. Ca(2+) had two actions that could be differentiat...
متن کامل